I do have sympathy for the immunocomprised who find they can now not at all safely circulate among humanity in an environment with Covid loose in humanity’s ecosystem.

But, yes, that’s what happens when a new highly infectious virus that can go several rounds with healthy individuals debuts, it becomes an environment incompatible with vulnerability for a while

I suppose now we at least know enough germ theory that we can even think of isolation as an option. And I suppose they were really often lucky to get to be immunocomprised in the first place, given how often that’s a side effect of something we figured to treat things lethal through all of human history until last generation.

Actually that’s a good question, is all that stuff practically dead-ended now? Do we just… lose the ability to do organ transplants for a millennia until humanity evolves genetic Covid defenses?